Non sedating antihistamine comparison
Non-sedating antihistamines are part of a quite heterogeneous pharmacological group.Bilastine has not been derived structurally from other antihistamines.Once an allergen is introduced to Ig E-sensitized mast cells, a degranulation is triggered which causes histamine to be released.The effects of histamines are mediated through several receptors including H1, H2, H3, and H4 receptors that belong to the superfamily of G-protein-coupled receptors .The biological effects of histamine in the allergic reaction are mediated through H1 receptors that coexist in active and inactive forms of g-protein-coupled receptors which balance each other.Histamine works as an agonist that pushes the balance to the active side leading to effects such as muscular contraction, bronchospasms, upregulation of endothelial permeability, and stimulation of sensory nerves and cough receptors .H1 antihistamines work as inverse agonists that drive the balance toward the inactive side and suppress the effects of histamine.Since these effects are not genuine antagonistic but rather represent a balance displacement between active and inactive forms of H1 receptors, now, the term H1 antihistamine rather than the former “antihistamine antagonist” is used .
Approximately, 95% is excreted intact in faeces (67%) or in urine (33%) . Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The aim of this paper is to review the current evidence of bilastine in the treatment of allergic rhinoconjunctivitis and urticaria.Several mediators are involved in the pathophysiology; however, histamine plays a vital role in the allergic immediate reaction .